A novel type of highly effective nonionic gemini alkyl O-glucoside surfactants: a versatile strategy of design

Langmuir. 2013 Jul 9;29(27):8511-6. doi: 10.1021/la401569n. Epub 2013 Jun 27.

Abstract

A novel type of highly effective gemini alkyl glucosides has been rationally designed and synthesized. The gemini surfactants have been readily prepared by glycosylation of the gemini alkyl chains that are synthesized with regioselective ring-opening of ethylene glycol epoxides by the alkyl alcohols. The new gemini alkyl glucosides exhibit significantly better surface activity than the known results. Then rheological, DLS, and TEM studies have revealed the intriguing self-assembly behavior of the novel gemini surfactants. This study has proved the effectiveness of the design of gemini alkyl glucosides which is modular, extendable, and synthetically simple. The new gemini surfactants have great potential as nano carriers in drug and gene delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glucosides / chemical synthesis
  • Glucosides / chemistry*
  • Molecular Structure
  • Particle Size
  • Surface Properties
  • Surface-Active Agents / chemical synthesis
  • Surface-Active Agents / chemistry*

Substances

  • Glucosides
  • Surface-Active Agents