Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla
- PMID: 23806072
- DOI: 10.1021/np3006937
Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla
Abstract
Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 μM.
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