Argonaute regulation: two roads to the same destination

Dev Cell. 2013 Jun 24;25(6):553-4. doi: 10.1016/j.devcel.2013.06.009.


Reporting recently in Nature and Nature Structural and Molecular Biology, Shen et al. (2013) and Smibert et al. (2013) uncover mechanisms for Argonaute (Ago) protein regulation. Smibert et al. find that microRNA availability controls Ago levels, and Shen et al. show that epidermal growth factor receptor-mediated Ago2 phosphorylation affects Ago loading.

Publication types

  • Comment

MeSH terms

  • Argonaute Proteins / chemistry*
  • Argonaute Proteins / metabolism*
  • Cell Hypoxia / physiology*
  • ErbB Receptors / metabolism*
  • Female
  • Humans
  • MicroRNAs / metabolism*


  • Argonaute Proteins
  • MicroRNAs
  • ErbB Receptors