Comparison of sevoflurane versus propofol under auditory evoked potential monitoring in female patients undergoing breast surgery

Biomed J. 2013 May-Jun;36(3):125-31. doi: 10.4103/2319-4170.113228.


Background: General anesthesia is used for most major surgeries, and the most common side effects include headache, nausea, vomiting, and sore throat. Major breast surgery is associated with a high incidence of postoperative nausea and vomiting (PONV). We compared the postoperative nausea and vomiting of propofol-based total intravenous anesthesia (TIVA) and sevoflurane (SEVO) anesthesia under auditory evoked potential (AEP) monitoring in female patients undergoing breast surgery.

Methods: A total of 84 patients scheduled to undergo elective breast surgery from 1 to 4 h in duration from March 2011 to December 2011 were prospectively included in the study. All participants were randomly assigned to TIVA or SEVO group. The AEP index was maintained at 15-25. After completing the surgery, the duration of surgery, emergence time, and the side effects of PONV were recorded.

Results: Patient characteristics, intraoperative and postoperative data, and the amounts of intraoperative analgesic drugs used were not significantly different between the TIVA and SEVO groups. The incidence of PONV was significantly higher in the SEVO group than in the TIVA group (50% and 14.3%, respectively; p < 0.001), and the total cost was significantly lower in the TIVA group than in the SEVO group (648 ± 185 and 850 ± 197, respectively).

Conclusion: We observed that when compared with sevoflurane, propofol given for the maintenance of general anesthesia improves the postoperative patient well-being and reduces the incidence of PONV. Furthermore, total intravenous anesthesia with propofol resulted in significant cost reductions.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anesthetics, Inhalation / pharmacology*
  • Anesthetics, Intravenous / pharmacology*
  • Breast / surgery*
  • Evoked Potentials, Auditory*
  • Female
  • Humans
  • Incidence
  • Methyl Ethers / pharmacology*
  • Middle Aged
  • Monitoring, Intraoperative*
  • Postoperative Nausea and Vomiting / epidemiology*
  • Propofol / pharmacology*
  • Prospective Studies
  • Sevoflurane


  • Anesthetics, Inhalation
  • Anesthetics, Intravenous
  • Methyl Ethers
  • Sevoflurane
  • Propofol