Acute immune thrombocytopenic purpura as adverse reaction to oral polio vaccine (OPV)

Hum Vaccin Immunother. 2013 Aug;9(8):1739-40. doi: 10.4161/hv.24847. Epub 2013 Jun 4.


A case of acute immune thrombocytopenic purpura following oral polio vaccine (OPV) is reported. An 82-d-old infant developed purpura at the same day after the second dose of oral polio vaccine. Until the time of hospital admission, the male infant had been in good health and had not received any drugs, and the possible causes of this condition were excluded. His platelet count was 13×10(9)/L. Platelet-associated IgG was elevated, but the amount of megakaryocytes in bone marrow aspirates was within the normal range, suggesting immune mechanism-associated thrombocytopenia. The infant recovered with the proper treatment within 30 d. Attention should be paid to OPV-associated thrombocytopenia, though it seems to be less frequent than after natural infections.

Keywords: acute immune thrombocytopenic purpura; adverse reaction; immune thrombocytopenic purpura; infant; infection; oral polio vaccine; polio vaccine.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / blood
  • Humans
  • Infant
  • Male
  • Platelet Count
  • Poliovirus Vaccine, Oral / administration & dosage*
  • Poliovirus Vaccine, Oral / adverse effects*
  • Purpura, Thrombocytopenic, Idiopathic / chemically induced*
  • Purpura, Thrombocytopenic, Idiopathic / pathology*


  • Autoantibodies
  • Poliovirus Vaccine, Oral