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. 2013 Jun 27;11(7):2282-92.
doi: 10.3390/md11072282.

Nepheliosyne B, a New Polyacetylenic Acid From the New Caledonian Marine Sponge Niphates Sp

Free PMC article

Nepheliosyne B, a New Polyacetylenic Acid From the New Caledonian Marine Sponge Niphates Sp

Nathalie Legrave et al. Mar Drugs. .
Free PMC article


A new C47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.


Figure 1
Figure 1
Structure of nepheliosynes A (1) and B (2).
Figure 2
Figure 2
Partial structures (a, a′, be) of nepheliosynes A (1) and B (2).
Figure 3
Figure 3
Niphates sp. (photo: Philippe Amade).

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