Effect of fullerene C60 on ATPase activity and superprecipitation of skeletal muscle actomyosin

Ukr Biokhim Zh (1999). 2013 Mar-Apr;85(2):20-6.


Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology. The effect of pristine water-soluble fullerene C60 on ATPase activity and superprecipitation reaction of rabbit skeletal muscle natural actomyosin has been revealed, namely an increase of actomyosin superprecipitation and Mg2+, Ca(2+)- and K(+)-ATPase activity by fullerene was investigated. We conclude that this finding offers a real possibility for the regulation of contraction-relaxation of skeletal muscle with fullerene C60.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actomyosin / metabolism*
  • Animals
  • Ca(2+) Mg(2+)-ATPase / metabolism*
  • Chemical Precipitation
  • Dose-Response Relationship, Drug
  • Fullerenes / chemistry
  • Fullerenes / pharmacology*
  • Ligands
  • Molecular Docking Simulation
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / enzymology
  • Muscle, Skeletal / metabolism
  • Nanoparticles / chemistry
  • Rabbits
  • Sodium-Potassium-Exchanging ATPase / metabolism*
  • Thermodynamics


  • Fullerenes
  • Ligands
  • Actomyosin
  • Ca(2+) Mg(2+)-ATPase
  • Sodium-Potassium-Exchanging ATPase
  • fullerene C60