Structural synaptic plasticity in the hippocampus induced by spatial experience and its implications in information processing

Neurologia. 2016 Oct;31(8):543-9. doi: 10.1016/j.nrl.2012.12.005. Epub 2013 Jun 28.
[Article in English, Spanish]

Abstract

Introduction: Long-lasting memory formation requires that groups of neurons processing new information develop the ability to reproduce the patterns of neural activity acquired by experience.

Development: Changes in synaptic efficiency let neurons organise to form ensembles that repeat certain activity patterns again and again. Among other changes in synaptic plasticity, structural modifications tend to be long-lasting which suggests that they underlie long-term memory. There is a large body of evidence supporting that experience promotes changes in the synaptic structure, particularly in the hippocampus.

Conclusion: Structural changes to the hippocampus may be functionally implicated in stabilising acquired memories and encoding new information.

Keywords: Ensambles neuronales; Experiencia espacial; Fibras musgosas; Hipocampo; Hippocampus; Long-term memory; Memoria a largo plazo; Mossy fibres; Neuronal ensembles; Plasticidad sináptica; Spatial experience; Synaptic plasticity.

Publication types

  • Review

MeSH terms

  • Hippocampus / physiology*
  • Humans
  • Memory, Long-Term
  • Mental Processes / physiology*
  • Neuronal Plasticity / physiology*
  • Space Perception / physiology*