Shedding light on nuclear actin dynamics and function

Trends Biochem Sci. 2013 Aug;38(8):376-7. doi: 10.1016/j.tibs.2013.06.004. Epub 2013 Jun 27.


The functions of nuclear actin have been a mystery for many years. Recent papers demonstrate that the nuclear and cytoplasmic actin pools are in dynamic communication, but that not all nuclear actin freely exchanges. Extracellular signals can induce changes in nuclear actin dynamics, affecting activity of the myocardin-related transcription factor (MRTF) transcriptional coactivators, which reversibly bind G-actin. By contrast, actin is stably associated with the Ino80 chromatin remodelling complex, where it plays a role in the recognition of nucleosome linker DNA.

Keywords: Arp4; Ino80; actin; actin dynamics; chromatin remodelling; mDia; myocardin-related transcription factor; nucleus.

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Actins / metabolism*
  • Animals
  • Cell Nucleus / metabolism*
  • Chromatin Assembly and Disassembly
  • Cytoplasm / genetics
  • Humans
  • Models, Biological*
  • Protein Transport
  • Signal Transduction


  • Actins