Identification of wheat gene Sr35 that confers resistance to Ug99 stem rust race group

Science. 2013 Aug 16;341(6147):783-786. doi: 10.1126/science.1239022. Epub 2013 Jun 27.


Wheat stem rust, caused by Puccinia graminis f. sp. tritici (Pgt), is a devastating disease that can cause severe yield losses. A previously uncharacterized Pgt race, designated Ug99, has overcome most of the widely used resistance genes and is threatening major wheat production areas. Here, we demonstrate that the Sr35 gene from Triticum monococcum is a coiled-coil, nucleotide-binding, leucine-rich repeat gene that confers near immunity to Ug99 and related races. This gene is absent in the A-genome diploid donor and in polyploid wheat but is effective when transferred from T. monococcum to polyploid wheat. The cloning of Sr35 opens the door to the use of biotechnological approaches to control this devastating disease and to analyses of the molecular interactions that define the wheat-rust pathosystem.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Basidiomycota* / pathogenicity
  • Cloning, Molecular
  • Disease Resistance / genetics
  • Genes, Plant*
  • Haplotypes
  • Molecular Sequence Annotation
  • Molecular Sequence Data
  • Mutation
  • Phylogeny
  • Plant Diseases / genetics
  • Plant Diseases / immunology*
  • Plant Diseases / microbiology
  • Plant Proteins / chemistry
  • Plant Proteins / genetics
  • Plant Stems / microbiology
  • Plants, Genetically Modified
  • Polymorphism, Single Nucleotide
  • Polyploidy
  • Sequence Analysis, DNA
  • Triticum / genetics*
  • Triticum / immunology
  • Triticum / microbiology


  • Plant Proteins

Associated data

  • GENBANK/KC573058
  • GENBANK/KC816724
  • GENBANK/KC876115
  • GENBANK/KC876116
  • GENBANK/KC876117
  • GENBANK/KC876118
  • GENBANK/KC876119
  • GENBANK/KC876120
  • GENBANK/KC876121
  • GENBANK/KF113354
  • GENBANK/KF113355
  • GENBANK/KF113356
  • GENBANK/KF113357