The Cinderella effect: searching for the best fit between mouse models and human diseases

J Invest Dermatol. 2013 Nov;133(11):2509-2513. doi: 10.1038/jid.2013.238. Epub 2013 Jun 27.

Abstract

A recent publication questions the suitability of mice as a model for the human inflammatory response and has fueled the continuing debate about the suitability of mice as models for human disease. We discuss recent advances in disease modeling using mice, and the genetic factors that need to be considered when trying to recapitulate aspects of human disease. Failure to appreciate the important differences between human and mouse biology and genetics underlying attempts to generate faithful models frequently leads to poor outcomes. Closely coordinated human and model organism studies are essential to provide traction for translational research.

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Humans
  • Mice
  • Mice, Inbred C57BL*
  • Skin Diseases*
  • Species Specificity
  • Translational Medical Research / methods*