Chromatin, non-coding RNAs, and the expression of HIV

Viruses. 2013 Jun 28;5(7):1633-45. doi: 10.3390/v5071633.


HIV is a chronic viral infection affecting an estimated 34 million people worldwide. Current therapies employ the use of a cocktail of antiretroviral medications to reduce the spread and effects of HIV, however complete eradication from an individual currently remains unattainable. Viral latency and regulation of gene expression is a key consideration when developing effective treatments. While our understanding of these processes remains incomplete new developments suggest that non-coding RNA (ncRNA) mediated regulation may provide an avenue to controlling both viral expression and latency. Here we discuss the importance of known regulatory mechanisms and suggest directions for further study, in particular the use ncRNAs in controlling HIV expression.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Chromatin / metabolism*
  • Gene Expression Regulation, Viral*
  • HIV / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • RNA, Untranslated / metabolism*
  • Virus Latency


  • Chromatin
  • RNA, Untranslated