Scalable manufacture of built-to-order nanomedicine: spray-assisted layer-by-layer functionalization of PRINT nanoparticles

Adv Mater. 2013 Sep 14;25(34):4707-13. doi: 10.1002/adma.201302025. Epub 2013 Jul 1.


Scalable methods, PRINT particle fabrication, and spray-assisted Layer-by-Layer deposition are combined to generate uniform and functional nanotechnologies with precise control over composition, size, shape, and surface functionality. A modular and tunable approach towards design of built-to-order nanoparticle systems, spray coating on PRINT particles is demonstrated to achieve technologies capable of targeted interactions with cancer cells for applications in drug delivery.

Keywords: core/shell nanoparticles; nanoimprinting; nanomedicine; thin films.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carbocyanines / chemistry
  • Cell Line, Tumor
  • Drug Carriers / chemistry
  • Humans
  • Lactic Acid / chemistry
  • Microscopy, Atomic Force
  • Microscopy, Confocal
  • Nanomedicine*
  • Nanoparticles / chemistry*
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polylysine / chemistry
  • Polyvinyl Alcohol / chemistry


  • Carbocyanines
  • Drug Carriers
  • cyanine dye 5
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polylysine
  • Polyglycolic Acid
  • Lactic Acid
  • Polyvinyl Alcohol