The omics in migraine

doi:10.1186/1129-2377-14-55

Review

. 2013 Jul 1;14(1):55.

doi: 10.1186/1129-2377-14-55.

The omics in migraine

Luana Lionetto¹, Giovanna Gentile, Elisa Bellei, Matilde Capi, Donata Sabato, Francesco Marsibilio, Maurizio Simmaco, Luigi Alberto Pini, Paolo Martelletti

Affiliations

PMID: 23815568
PMCID: PMC3727988
DOI: 10.1186/1129-2377-14-55

Free PMC article

Review

The omics in migraine

Luana Lionetto et al. J Headache Pain. 2013.

Free PMC article

. 2013 Jul 1;14(1):55.

doi: 10.1186/1129-2377-14-55.

Authors

Luana Lionetto¹, Giovanna Gentile, Elisa Bellei, Matilde Capi, Donata Sabato, Francesco Marsibilio, Maurizio Simmaco, Luigi Alberto Pini, Paolo Martelletti

Affiliation

¹ Sant'Andrea Hospital, Advanced Molecular Diagnostics Unit, Via di Grottarossa 1035 - 1039, Rome 00189, Italy. luanalionetto@gmail.com.

PMID: 23815568
PMCID: PMC3727988
DOI: 10.1186/1129-2377-14-55

Abstract

The term omics consist of three main areas of molecular biology, such as genomics, proteomics and metabolomics. The omics synergism recognise migraine as an ideal study model, due to its multifactorial nature. In this review, the plainly research data featuring in this complex network are reported and analyzed, as single or multiple factor in pathophysiology of migraine. The future of migraine biomolecular research shall be focused on networking among these different and hierarchical disciplines. We have to look for its Ariadne's tread, in order to see the whole painting of migraine molecular biology.

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Figures

**Figure 1**
**Framework of the multiple interactions taking place in the migraine** ***omics*** **scenario.**

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References

1. Simmaco M, Borro M, Missori S, Martelletti P. Pharmacogenomics in migraine: catching biomarkers for a predictable disease control. Expert Rev Neurother. 2009;14(9):1267–1269. doi: 10.1586/ern.09.80. - DOI - PubMed
1. Chen T, Murrell M, Fowdar J, Roy B, Grealy R, Griffiths LR. Investigation of the role of the GABRG2 gene variant in migraine. J Neurol Sci. 2012;14(1-2):112–114. doi: 10.1016/j.jns.2012.03.014. 15. - DOI - PubMed
1. Carreño O, Corominas R, Fernández-Morales J, Camiña M, Sobrido MJ, Fernández-Fernández JM, Pozo-Rosich P, Cormand B, Macaya A. SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet. 2012;14(1):94–103. doi: 10.1002/ajmg.b.32007. - DOI - PubMed
1. Geppetti P, Rossi E, Chiarugi A, Benemei S. Antidromic vasodilatation and the migraine mechanism. J Headache Pain. 2012;14(2):103–111. doi: 10.1007/s10194-011-0408-3. - DOI - PMC - PubMed
1. Cox HC, Lea RA, Bellis C, Carless M, Dyer T, Blangero J, Griffiths LR. Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate. J Headache Pain. 2011;14(6):603–608. doi: 10.1007/s10194-011-0392-7. - DOI - PMC - PubMed

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[1] Simmaco M, Borro M, Missori S, Martelletti P. Pharmacogenomics in migraine: catching biomarkers for a predictable disease control. Expert Rev Neurother. 2009;14(9):1267–1269. doi: 10.1586/ern.09.80. - DOI - PubMed

[2] Simmaco M, Borro M, Missori S, Martelletti P. Pharmacogenomics in migraine: catching biomarkers for a predictable disease control. Expert Rev Neurother. 2009;14(9):1267–1269. doi: 10.1586/ern.09.80. - DOI - PubMed

[3] Chen T, Murrell M, Fowdar J, Roy B, Grealy R, Griffiths LR. Investigation of the role of the GABRG2 gene variant in migraine. J Neurol Sci. 2012;14(1-2):112–114. doi: 10.1016/j.jns.2012.03.014. 15. - DOI - PubMed

[4] Chen T, Murrell M, Fowdar J, Roy B, Grealy R, Griffiths LR. Investigation of the role of the GABRG2 gene variant in migraine. J Neurol Sci. 2012;14(1-2):112–114. doi: 10.1016/j.jns.2012.03.014. 15. - DOI - PubMed

[5] Carreño O, Corominas R, Fernández-Morales J, Camiña M, Sobrido MJ, Fernández-Fernández JM, Pozo-Rosich P, Cormand B, Macaya A. SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet. 2012;14(1):94–103. doi: 10.1002/ajmg.b.32007. - DOI - PubMed

[6] Carreño O, Corominas R, Fernández-Morales J, Camiña M, Sobrido MJ, Fernández-Fernández JM, Pozo-Rosich P, Cormand B, Macaya A. SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet. 2012;14(1):94–103. doi: 10.1002/ajmg.b.32007. - DOI - PubMed

[7] Geppetti P, Rossi E, Chiarugi A, Benemei S. Antidromic vasodilatation and the migraine mechanism. J Headache Pain. 2012;14(2):103–111. doi: 10.1007/s10194-011-0408-3. - DOI - PMC - PubMed

[8] Geppetti P, Rossi E, Chiarugi A, Benemei S. Antidromic vasodilatation and the migraine mechanism. J Headache Pain. 2012;14(2):103–111. doi: 10.1007/s10194-011-0408-3. - DOI - PMC - PubMed

[9] Cox HC, Lea RA, Bellis C, Carless M, Dyer T, Blangero J, Griffiths LR. Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate. J Headache Pain. 2011;14(6):603–608. doi: 10.1007/s10194-011-0392-7. - DOI - PMC - PubMed

[10] Cox HC, Lea RA, Bellis C, Carless M, Dyer T, Blangero J, Griffiths LR. Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate. J Headache Pain. 2011;14(6):603–608. doi: 10.1007/s10194-011-0392-7. - DOI - PMC - PubMed

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The omics in migraine

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