Metastatic prostate cancer proven by 18F-FCH PET/CT staging scan in patient with normal PSA but high PSA doubling time

Clin Nucl Med. 2013 Sep;38(9):739-40. doi: 10.1097/RLU.0b013e31829b9d6b.

Abstract

A 59-year-old man presented with frequent urination. Six months ago, his prostate-specific antigen (PSA) was 1.56 ng/mL; currently it is 3.5 ng/mL (PSA doubling time = 6 months; PSA velocity = 0.19 ng/mL/mo). Biopsy revealed aggressive prostate cancer (Gleason score 5 + 5). Staging with (18)F-fluorocholine PET/CT ((18)F-FCH PET/CT) demonstrated lymph node metastasis. After 6 months of hormonal therapy with goserelin, PSA decreased to 0.38 ng/mL. A (18)F-FCH PET/CT restaging scan demonstrated a global reduction of (18)F-FCH lesion uptake with disappearance of some mediastinal and iliac pelvic lymph node activity.

Publication types

  • Case Reports

MeSH terms

  • Choline / analogs & derivatives*
  • Fluorine Radioisotopes
  • Humans
  • Lymphatic Metastasis / diagnostic imaging*
  • Male
  • Middle Aged
  • Positron-Emission Tomography*
  • Prostate-Specific Antigen / metabolism*
  • Prostatic Neoplasms / diagnostic imaging*
  • Tomography, X-Ray Computed*

Substances

  • Fluorine Radioisotopes
  • fluorocholine
  • Prostate-Specific Antigen
  • Choline