Identification and characterization of a twist ortholog in the polychaete annelid Platynereis dumerilii reveals mesodermal expression of Pdu-twist

Dev Genes Evol. 2013 Sep;223(5):319-28. doi: 10.1007/s00427-013-0448-6. Epub 2013 Jul 2.


The basic helix-loop-helix transcription factor twist plays a key role during mesoderm development in Bilateria. In this study, we identified a twist ortholog in the polychaete annelid Platynereis dumerilii and analyze its expression during larval development, postlarval growth up to the adult stage, and caudal regeneration after amputation of posterior segments. At late larval stages, Pdu-twist is expressed in the mesodermal anlagen and in developing muscles. During adulthood and caudal regeneration, Pdu-twist is expressed in the posterior growth zone, in mesodermal cells within the newly forming segments and budding parapodia. Our results indicate that Pdu-twist is involved in mesoderm formation during larval development, posterior growth, and caudal regeneration.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Embryo, Nonmammalian / metabolism
  • Gene Expression Regulation, Developmental
  • Mesoderm / metabolism
  • Molecular Sequence Data
  • Phylogeny
  • Polychaeta / embryology*
  • Polychaeta / metabolism*
  • Twist-Related Protein 1 / chemistry
  • Twist-Related Protein 1 / genetics*
  • Twist-Related Protein 1 / metabolism*


  • Twist-Related Protein 1