CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease

Database (Oxford). 2013 Jul 1:2013:bat047. doi: 10.1093/database/bat047. Print 2013.


Coronary heart disease (CHD), the leading cause of global morbidity and mortality in adults, has been reported to be associated with hundreds of genes. A comprehensive understanding of the CHD-related genes and their corresponding interactions is essential to advance the translational research on CHD. Accordingly, we construct this knowledgebase, CHD@ZJU, which records CHD-related information (genes, pathways, drugs and references) collected from different resources and through text-mining method followed by manual confirmation. In current release, CHD@ZJU contains 660 CHD-related genes, 45 common pathways and 1405 drugs accompanied with >8000 supporting references. Almost half of the genes collected in CHD@ZJU were novel to other publicly available CHD databases. Additionally, CHD@ZJU incorporated the protein-protein interactions to investigate the cross-talk within the pathways from a multi-layer network view. These functions offered by CHD@ZJU would allow researchers to dissect the molecular mechanism of CHD in a systematic manner and therefore facilitate the research on CHD-related multi-target therapeutic discovery. Database URL:

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coronary Disease* / drug therapy
  • Coronary Disease* / genetics
  • Coronary Disease* / metabolism
  • Data Mining
  • Databases, Genetic*
  • Humans
  • Knowledge Bases*
  • Research*
  • Search Engine
  • Signal Transduction* / genetics
  • User-Computer Interface