[Study of the effect of vinblastine on hair growth in rats]

Przegl Dermatol. 1990 Jan-Feb;77(1):14-9.
[Article in Polish]

Abstract

In the trichological studies on the model of Wistar rats aged 4-5 weeks intraperitoneal vinblastine in doses of 0.008-0.030 mg/100 g of body weight caused initially mixed (dystrophic-telogenic) hair loss. After higher doses and longer drug administration the mechanism of hair loss was transformed to dystrophic. In both forms of hair loss signs of advanced diffuse alopecia were found.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Alopecia / chemically induced*
  • Animals
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Hair / drug effects*
  • Hair / growth & development
  • Injections, Intraperitoneal
  • Male
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • Vinblastine / administration & dosage
  • Vinblastine / adverse effects*

Substances

  • Vinblastine