Golgi as an MTOC: making microtubules for its own good

Histochem Cell Biol. 2013 Sep;140(3):361-7. doi: 10.1007/s00418-013-1119-4. Epub 2013 Jul 3.


In cells, microtubules (MTs) are nucleated at MT-organizing centers (MTOCs). The centrosome-based MTOCs organize radial MT arrays, which are often not optimal for polarized trafficking. A recently discovered subset of non-centrosomal MTs nucleated at the Golgi has proven to be indispensable for the Golgi organization, post-Golgi trafficking and cell polarity. Here, we summarize the history of this discovery, known molecular prerequisites of MT nucleation at the Golgi and unique functions of Golgi-derived MTs.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Golgi Apparatus / metabolism*
  • Humans
  • Microtubule-Organizing Center / metabolism*
  • Microtubules / metabolism*