Quality of life in lung transplantation

Semin Respir Crit Care Med. 2013 Jun;34(3):421-30. doi: 10.1055/s-0033-1348470. Epub 2013 Jul 2.


Improving health-related quality of life is an important goal of lung transplantation. This review describes background concepts, including definitions, measurement and interpretation of health-related quality of life (HRQL), and other patient-reported outcomes. Lung transplantation is associated with dramatic and sustained improvements in HRQL, particularly in measures of physical health and functioning. Physical rehabilitation may augment the early improvements in HRQL, whereas bronchiolitis obliterans syndrome and psychological conditions have a negative impact. More research is needed, particularly longitudinal, multicenter studies, to better understand the trajectory and determinants of HRQL after lung transplantation, and the impact of targeted interventions to improve HRQL.

Publication types

  • Review

MeSH terms

  • Bronchiolitis Obliterans / epidemiology*
  • Bronchiolitis Obliterans / etiology
  • Humans
  • Lung Transplantation / methods*
  • Lung Transplantation / rehabilitation
  • Outcome Assessment, Health Care
  • Quality of Life*
  • Research Design
  • Time Factors
  • Treatment Outcome