Microfluidic platforms for single-cell protein analysis

J Lab Autom. 2013 Dec;18(6):446-54. doi: 10.1177/2211068213494389. Epub 2013 Jul 2.


Elucidation of the heterogeneity of cells is a challenging task due to the lack of efficient analytical tools to make measurements with single-cell resolution. Microfluidics has emerged as a powerful platform for single-cell analysis with the ability to manipulate small volume and integrate multiple sample preparation steps into one device. In this review, we discuss the differentiating advantages of microfluidic platforms that have been demonstrated for single-cell protein analysis.

Keywords: droplet; heterogeneity; laminar flow; microfluidics; protein analysis; single cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biomedical Research / instrumentation
  • Biomedical Research / methods
  • Microfluidics / instrumentation*
  • Microfluidics / methods*
  • Proteins / analysis*
  • Single-Cell Analysis / instrumentation*
  • Single-Cell Analysis / methods*


  • Proteins