SIMIBI twins in protein targeting and localization

Nat Struct Mol Biol. 2013 Jul;20(7):776-80. doi: 10.1038/nsmb.2605.


Signal recognition particle, MinD and BioD (SIMIBI)-type nucleoside triphosphate-binding proteins are an ancient subfamily of nucleotide-binding proteins that serve in a wide range of cellular processes. Notably, this class comprises dimeric ATPases as well as GTPases (SIMIBI 'twins') and a subset of SIMIBI-type proteins, including SRP GTPases, MinD-type ATPases and the Get3 ATPase, is essential to protein targeting and localization. Here, we define common mechanistic principles and differences for these SIMIBI proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / chemistry*
  • Adenosine Triphosphatases / metabolism
  • Bacteria / chemistry
  • Bacteria / metabolism*
  • Carrier Proteins / chemistry*
  • Carrier Proteins / metabolism
  • GTP Phosphohydrolases / chemistry*
  • GTP Phosphohydrolases / metabolism
  • Models, Biological
  • Models, Molecular
  • Protein Multimerization*
  • Protein Transport*


  • Carrier Proteins
  • Adenosine Triphosphatases
  • GTP Phosphohydrolases