Circulating miRNAs: cell-cell communication function?

Front Genet. 2013 Jun 28;4:119. doi: 10.3389/fgene.2013.00119. Print 2013.

Abstract

Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell-cell signaling function during various physiological and pathological processes. In this review, we discuss the state-of-the-art in the field of intercellular miRNA transport and highlight current theories regarding the origin and the biological function of extracellular miRNAs.

Keywords: HDL; argonaute proteins; biofluids; biomarkers; cell communication; exosomes; miRNA; microvesicles.