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, 33 (4), 297-9

Extra X Chromosome in Mosaic Klinefelter Syndrome Is Associated With a Hematologic Malignancy

Case Reports

Extra X Chromosome in Mosaic Klinefelter Syndrome Is Associated With a Hematologic Malignancy

Mi-Ae Jang et al. Ann Lab Med.

Conflict of interest statement

No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Karyotyping of peripheral blood cells using conventional G-banding revealed an extra X chromosome.
Fig. 2
Fig. 2
FISH analyses using sex chromosome-specific probes to the α-satellite of the X centromere region (red signal) and satellite III of Yq12 (green signal) on a buccal smear specimen revealed 86% XXY and 11.5% XY. The remaining 2.5% of cells had an XX signal pattern, probably due to the artificial loss of 1 Y chromosome in the FISH procedure or true mosaicism with 3 cell lines.

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References

    1. Wikström AM, Dunkel L. Klinefelter syndrome. Best Pract Res Clin Endocrinol Metab. 2011;25:239–250. - PubMed
    1. Yamamoto K, Hato A, Minagawa K, Yakushijin K, Urahama N, Sada A, et al. An extra X chromosome as a sole abnormality in relapse of an adult acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2004;155:154–155. - PubMed
    1. Tsutsumi Y, Tanaka J, Minami H, Musashi M, Fukushima A, Ehira N, et al. Acute biphenotypic leukemia and an acquired X chromosome. Cancer Genet Cytogenet. 2005;157:94–95. - PubMed
    1. Wan TS, Yip SF, Yeung YM, Chan LC, Ma SK. Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X. Ann Hematol. 2002;81:167–169. - PubMed
    1. Yamamoto K, Nagata K, Kida A, Hamaguchi H. Acquired gain of an X chromosome as the sole abnormality in the blast crisis of chronic neutrophilic leukemia. Cancer Genet Cytogenet. 2002;134:84–87. - PubMed
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