lincRNAs: genomics, evolution, and mechanisms

Cell. 2013 Jul 3;154(1):26-46. doi: 10.1016/j.cell.2013.06.020.


Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and other cellular processes. This Review outlines the emerging understanding of lincRNAs in vertebrate animals, with emphases on how they are being identified and current conclusions and questions regarding their genomics, evolution and mechanisms of action.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Evolution, Molecular
  • Gene Expression Regulation*
  • Humans
  • RNA, Long Noncoding / chemistry
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / isolation & purification
  • RNA, Long Noncoding / metabolism*
  • Transcription, Genetic


  • RNA, Long Noncoding