Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity

Cell Stem Cell. 2013 Jul 3;13(1):5-6. doi: 10.1016/j.stem.2013.06.012.

Abstract

Pathways that regulate epigenetic control of stem cell identity are critical to the molecular etiology of cancer. In back-to-back articles in Cell and Cell Stem Cell, Song et al. identify miR-22 as both a repressor of TET proteins and a powerful oncogene in the mammary epithelium and hematopoietic system.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / pathology*
  • Cell Transformation, Neoplastic / pathology*
  • Chromatin Assembly and Disassembly*
  • DNA-Binding Proteins / metabolism*
  • Epithelial-Mesenchymal Transition*
  • Gene Expression Regulation, Neoplastic*
  • Hematologic Neoplasms / pathology*
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • MicroRNAs / metabolism*
  • MicroRNAs / physiology
  • Myelodysplastic Syndromes / pathology*
  • Neoplasm Metastasis*
  • Neoplastic Stem Cells / metabolism*
  • Proto-Oncogene Proteins / metabolism*

Substances

  • DNA-Binding Proteins
  • MicroRNAs
  • Mirn22 microRNA, mouse
  • Proto-Oncogene Proteins
  • TET2 protein, human