Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths

Nat Rev Immunol. 2013 Aug;13(8):607-14. doi: 10.1038/nri3476. Epub 2013 Jul 5.

Abstract

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Adaptive Immunity*
  • Animals
  • Helminthiasis / immunology*
  • Helminthiasis / parasitology
  • Helminths / immunology*
  • Humans
  • Immune Tolerance
  • Inflammation / immunology
  • Inflammation / parasitology
  • Interleukin-10 / metabolism
  • Interleukin-13 / metabolism
  • Interleukin-4 / metabolism
  • Macrophages / immunology
  • T-Lymphocytes, Helper-Inducer / immunology*
  • Wound Healing / immunology*

Substances

  • Interleukin-13
  • Interleukin-10
  • Interleukin-4