Clinical pregnancy after uterus transplantation

Fertil Steril. 2013 Nov;100(5):1358-63. doi: 10.1016/j.fertnstert.2013.06.027. Epub 2013 Jul 3.


Objective: To present the first clinical pregnancy after uterus transplantation.

Design: Case study.

Setting: Tertiary center.

Patient(s): A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.

Intervention(s): Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.

Main outcome measure(s): Implantation of embryo in an allografted human uterus.

Result(s): The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.

Conclusion(s): We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.

Keywords: Uterus transplantation; clinical pregnancy; uterine factor infertility.

Publication types

  • Case Reports

MeSH terms

  • 46, XX Disorders of Sex Development / physiopathology
  • 46, XX Disorders of Sex Development / surgery*
  • Abortion, Spontaneous / etiology
  • Congenital Abnormalities / physiopathology
  • Congenital Abnormalities / surgery*
  • Embryo Implantation
  • Embryo Transfer
  • Female
  • Fertility Agents, Female / therapeutic use
  • Fertility*
  • Fertilization in Vitro
  • Gestational Age
  • Humans
  • Infertility, Female / physiopathology
  • Infertility, Female / surgery*
  • Mullerian Ducts / abnormalities*
  • Mullerian Ducts / physiopathology
  • Mullerian Ducts / surgery
  • Pregnancy
  • Treatment Outcome
  • Uterus / abnormalities
  • Uterus / physiopathology
  • Uterus / surgery*
  • Young Adult


  • Fertility Agents, Female

Supplementary concepts

  • Mullerian aplasia