Assessment of EIB: What you need to know to optimize test results

Immunol Allergy Clin North Am. 2013 Aug;33(3):363-80, viii. doi: 10.1016/j.iac.2013.02.006. Epub 2013 Apr 4.


Respiratory symptoms and asthma control questionnaires are poor predictors of the presence or severity of exercise-induced bronchoconstriction (EIB), and objective measurement is recommended. To optimize the chance of a positive test result, there are several factors to consider when exercising patients for EIB, including the ventilation achieved and sustained during exercise, water content of the inspired air, and the natural variability of the response. The high rate of negative exercise test results has led to the development of surrogates to identify EIB in laboratory or office settings, including eucapnic voluntary hyperpnea of dry air and inhalation of hyperosmolar aerosols.

Keywords: Bronchial provocation; Dry air; Exercise hyperpnea; Mannitol; Voluntary hyperpnea.

Publication types

  • Review

MeSH terms

  • Asthma, Exercise-Induced / diagnosis*
  • Bronchial Provocation Tests
  • Humans
  • Respiratory Function Tests
  • Sensitivity and Specificity