Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. Apr-Jun 2013;27(2):291-5.

Role of Vitamins D, E and C in Immunity and Inflammation

  • PMID: 23830380
Editorial

Role of Vitamins D, E and C in Immunity and Inflammation

Y B Shaik-Dasthagirisaheb et al. J Biol Regul Homeost Agents. .

Abstract

Inflammatory responses are operationally characterized by pain, redness, heat and swelling at the site of infection and trauma. Mast cells reside near small blood vessels and, when activated, release potent mediators involved in allergy and inflammation. Vitamin D modulates contraction, inflammation and remodeling tissue. Vitamin D deficiency has been linked to multiple diseases and several data have demonstrated a strong relationship between serum vitamin D levels and tissue function. Therapy targeting vitamin D3 signaling may provide new approaches for infectious and inflammatory skin diseases by affecting both innate and adaptive immune functions. Mast cells are activated by oxidized lipoproteins, resulting in increased expression of inflammatory cytokines and suggesting that the reduction of oxidation of low density lipoprotein by vitamin E may also reduce mast cell activation. Vitamin C is also an anti-oxidant well-known as an anti-scurvy agent in humans. Vitamin C inhibits peroxidation of membrane phospholipids and acts as a scavenger of free radicals and is also required for the synthesis of several hormones and neurotransmitters. In humans, vitamin C reduces the duration of common cold symptoms, even if its effect is not clear. Supplementation of vitamin C improves the function of the human immune system, such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis and delayed-type hypersensitivity. Vitamin C depletion has been correlated with histaminemia which has been shown to damage endothelial-dependent vasodilation. However, the impact of these vitamins on allergy and inflammation is still not well understood.

Similar articles

  • Immune-enhancing role of vitamin C and zinc and effect on clinical conditions.
    Wintergerst ES, Maggini S, Hornig DH. Wintergerst ES, et al. Ann Nutr Metab. 2006;50(2):85-94. doi: 10.1159/000090495. Epub 2005 Dec 21. Ann Nutr Metab. 2006. PMID: 16373990 Review.
  • Interrelationship between vitamins and cytokines in immunity.
    Castellani ML, Shaik-Dasthagirisaheb YB, Tripodi D, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Fulcheri M, Tetè S, Galzio R, Salini V, Caraffa A, Antinolfi P, Frydas I, Sabatino G, Kempuraj D. Castellani ML, et al. J Biol Regul Homeost Agents. 2010 Oct-Dec;24(4):385-90. J Biol Regul Homeost Agents. 2010. PMID: 21122276 Review.
  • Vitamins as hormones.
    Reichrath J, Lehmann B, Carlberg C, Varani J, Zouboulis CC. Reichrath J, et al. Horm Metab Res. 2007 Feb;39(2):71-84. doi: 10.1055/s-2007-958715. Horm Metab Res. 2007. PMID: 17326003 Review.
  • The history of vitamin research. Selected aspects.
    Morton RA. Morton RA. Int Z Vitaminforsch. 1968;38(1):5-44. Int Z Vitaminforsch. 1968. PMID: 4882103 No abstract available.
  • Mast cells and inflammation.
    Stassen M, Hültner L, Müller C, Schmitt E. Stassen M, et al. Arch Immunol Ther Exp (Warsz). 2002;50(3):179-85. Arch Immunol Ther Exp (Warsz). 2002. PMID: 12098933 Review.
See all similar articles

Cited by 9 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback