Experimental use of semiconductor diode laser in contact transscleral cyclophotocoagulation in rabbits

Arch Ophthalmol. 1990 Aug;108(8):1152-7. doi: 10.1001/archopht.1990.01070100108044.


Acute and long-term effects of contact transscleral semiconductor diode laser cyclophotocoagulation were studied in rabbits. Immediately following cyclophotocoagulation, light microscopy revealed coagulation necrosis of the ciliary pigmented and nonpigmented epithelia and stroma; destruction increased in relation to power. There was architectural disruption with higher energy levels. The findings with diode and continuous-wave contact neodymium-YAG lasers were similar. In rabbits treated and followed up for 6 weeks there was a decrease in intraocular pressure during the observation period (P less than .05, paired Student's t test). The gross and light microscopic examination revealed focal atrophy and fibrosis of the ciliary processes, with pigment-laden macrophages on the ciliary processes and in the outflow pathways. Higher energy levels caused lens capsule damage and vitritis. The diode laser produced ciliary destruction similar to the continuous-wave contact neodymium-YAG laser in rabbits, with significant intraocular pressure lowering during the 6-week follow-up.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Atrophy
  • Ciliary Body / pathology
  • Ciliary Body / surgery*
  • Ciliary Body / ultrastructure
  • Intraocular Pressure
  • Laser Therapy*
  • Light Coagulation*
  • Microscopy, Electron, Scanning
  • Postoperative Period
  • Rabbits
  • Sclera / surgery
  • Semiconductors
  • Time Factors