Abstract
The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn results in a reduction in egg-yolk cholesterol.
MeSH terms
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Animals
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Chickens / physiology*
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Cholesterol / metabolism
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Diet*
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Hydroxymethylglutaryl CoA Reductases / metabolism*
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
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Liver / drug effects
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Liver / enzymology*
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Liver / metabolism
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Oviposition / drug effects*
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Ubiquinone / analogs & derivatives*
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Ubiquinone / pharmacology
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Ubiquinone
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Cholesterol
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Hydroxymethylglutaryl CoA Reductases
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coenzyme Q10