Dietary coenzyme Q10 suppressed hepatic hydroxymethylglutaryl-CoA reductase activity in laying hens

Biosci Biotechnol Biochem. 2013;77(7):1572-4. doi: 10.1271/bbb.130039. Epub 2013 Jul 7.

Abstract

The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn results in a reduction in egg-yolk cholesterol.

MeSH terms

  • Animals
  • Chickens / physiology*
  • Cholesterol / metabolism
  • Diet*
  • Hydroxymethylglutaryl CoA Reductases / metabolism*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Liver / drug effects
  • Liver / enzymology*
  • Liver / metabolism
  • Oviposition / drug effects*
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Ubiquinone
  • Cholesterol
  • Hydroxymethylglutaryl CoA Reductases
  • coenzyme Q10