Effect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: a randomized, placebo-controlled, double-blind clinical trial

Indian J Pharmacol. 2013 May-Jun;45(3):217-22. doi: 10.4103/0253-7613.111894.


Background: Breast cancer (BC) represents the highest incidence of malignancy in women throughout the world. Medicinal fungi can stimulate the body, reduce side-effects associated with chemotherapy and improve the quality of life in patients with cancer.

Aim: To evaluate the effects of dietary supplementation of Agaricus sylvaticus on clinical and nutritional parameters in BC patients undergoing chemotherapy.

Materials and methods: A randomized, placebo-controlled, double-blind, clinical trial was carried out at the Oncology Clinic, Hospital of the Federal District-Brazil from September 2007 to July 2009. Forty six patients with BC, Stage II and III, were randomly assigned to receive either nutritional supplement with A. sylvaticus (2.1 g/day) or placebo. Patients were evaluated during treatment period.

Results: Patient supplemented with A. sylvaticus improved in clinical parameters and gastrointestinal functions. Poor appetite decreased by 20% with no changes in bowel functions (92.8%), nausea and vomiting (80%).

Conclusion: Dietary supplementation with A. sylvaticus improved nutritional status and reduced abnormal bowel functions, nausea, vomiting, and anorexia in patients with BC receiving chemotherapy.

Keywords: Agaricus sylvaticus; chemotherapy side effects; nutritional status.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Agaricus*
  • Antineoplastic Agents / adverse effects
  • Breast Neoplasms / drug therapy*
  • Complex Mixtures / pharmacology*
  • Dietary Supplements*
  • Double-Blind Method
  • Drug-Related Side Effects and Adverse Reactions / prevention & control*
  • Female
  • Humans
  • Middle Aged
  • Nutritional Status / drug effects


  • Antineoplastic Agents
  • Complex Mixtures