Rapid forward-in-time simulation at the chromosome and genome level

BMC Bioinformatics. 2013 Jul 9;14:216. doi: 10.1186/1471-2105-14-216.

Abstract

Background: In population genetics, simulation is a fundamental tool for analyzing how basic evolutionary forces such as natural selection, recombination, and mutation shape the genetic landscape of a population. Forward simulation represents the most powerful, but, at the same time, most compute-intensive approach for simulating the genetic material of a population.

Results: We introduce AnA-FiTS, a highly optimized forward simulation software, that is up to two orders of magnitude faster than current state-of-the-art software. In addition, we present a novel algorithm that further improves runtimes by up to an additional order of magnitude, for simulations where a fraction of the mutations is neutral (e.g., only 10% of mutations have an effect on fitness). Apart from simulated sequences, our tool also generates a graph structure that depicts the complete observable history of neutral mutations.

Conclusions: The substantial performance improvements allow for conducting forward simulations at the chromosome and genome level. The graph structure generated by our algorithm can give rise to novel approaches for visualizing and analyzing the output of forward simulations.

MeSH terms

  • Algorithms
  • Base Sequence / genetics
  • Biological Evolution
  • Chromosome Breakpoints*
  • Computer Simulation*
  • DNA Breaks, Double-Stranded*
  • Genetics, Population*
  • Genome*
  • Mutation*
  • Recombination, Genetic
  • Selection, Genetic
  • Software
  • Time