Gold-mediated synthesis and functionalization of chiral halopyridones

Khanh Hung Nguyen; Sophie Tomasi; Myriam Le Roch; Loïc Toupet; Jacques Renault; Philippe Uriac; Nicolas Gouault

doi:10.1021/jo400827b

Gold-mediated synthesis and functionalization of chiral halopyridones

J Org Chem. 2013 Aug 16;78(16):7809-15. doi: 10.1021/jo400827b. Epub 2013 Aug 1.

Authors

Khanh Hung Nguyen¹, Sophie Tomasi, Myriam Le Roch, Loïc Toupet, Jacques Renault, Philippe Uriac, Nicolas Gouault

Affiliation

¹ Equipe PNSCM, UMR 6226, Université de Rennes 1, 2 avenue du Pr. Léon Bernard 35043 Rennes Cedex, France.

PMID: 23834720
DOI: 10.1021/jo400827b

Abstract

A rapid and efficient one-step halopyridone synthesis has been developed based on gold-catalyzed cyclization of β-amino-ynone intermediates and halodeauration process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclization
Gold / chemistry*
Hydrocarbons, Halogenated / chemical synthesis*
Hydrocarbons, Halogenated / chemistry
Molecular Structure
Pyridones / chemical synthesis*
Pyridones / chemistry

Substances

Hydrocarbons, Halogenated
Pyridones
Gold