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Review
. 2013 Sep 1;5(9):a012930.
doi: 10.1101/cshperspect.a012930.

Regulating DNA Replication in Eukarya

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Free PMC article
Review

Regulating DNA Replication in Eukarya

Khalid Siddiqui et al. Cold Spring Harb Perspect Biol. .
Free PMC article

Abstract

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent kinase (CDK) and anaphase-promoting complex/cyclosome (APC/C) activities provide a binary switch that permits the replication of each chromosome exactly once per cell cycle. Work from several organisms has revealed a conserved strategy whereby inactive replication complexes are assembled onto DNA during periods of low CDK and high APC activity but are competent to execute genome duplication only when these activities are reversed. Periods of high CDK and low APC/C serve an essential function by blocking reassembly of replication complexes, thereby preventing rereplication. Higher eukaryotes have evolved additional CDK-independent mechanisms for preventing rereplication.

Figures

Figure 1.
Figure 1.
Regulation of DNA replication in the cell cycle. A generic diagram summarizing the oscillation of CDK activity in the cell cycle in response to the fluctuation of APC/C activity and the presence of CDK inhibitor (CKI). The details of regulation in different organisms are described in the corresponding sections of the article.

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