Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 18 (4), 408-15

Cell Therapy as a Strategy to Minimize Maintenance Immunosuppression in Solid Organ Transplant Recipients

Affiliations
Review

Cell Therapy as a Strategy to Minimize Maintenance Immunosuppression in Solid Organ Transplant Recipients

Edward K Geissler et al. Curr Opin Organ Transplant.

Abstract

Purpose of review: This review presents a clinically focussed introduction to cell-based immunotherapy in solid organ transplantation. The potential benefits and risks of cell-based immunotherapeutics are critically discussed.

Recent findings: The use of immunoregulatory cells as medicinal agents is very much in its infancy, but the field is expanding rapidly. In principle, this approach permits manipulation of specific immunological functions, opening new possibilities in the field of tolerance-promoting therapies. Several immunoregulatory cell types have reached the point of preclinical and clinical development that should allow them to be tested in early-phase clinical trials. Solid organ transplantation represents an important potential indication for the use of cell-based immunosuppressive agents because promoting immunological regulation towards allografts remains a promising strategy for preventing chronic rejection.

Summary: Remarkable progress is being made in the implementation of novel cell-based immunotherapeutics in solid organ transplantation studies. It is hoped that these new immunoregulatory therapies will afford better long-term transplant outcomes by mitigating chronic graft injury.

Similar articles

  • New Directions for Induction Immunosuppression Strategy in Solid Organ Transplantation
    JS Hawksworth et al. Am J Surg 197 (4), 515-24. PMID 19249743. - Review
    While current induction immunosuppression agents have reduced the incidence of acute rejection, the goal of transplant tolerance has not been realized. Furthermore, the l …
  • Pharmacological Manipulation of the Rejection Response
    PM Hopkins. Methods Mol Biol 333, 375-400. PMID 16790860. - Review
    Immunosuppressive strategies continue to evolve, with a number of new formulations having been developed in recent years. Although acute rejection rates may have diminish …
  • Some Observations on Prope Tolerance
    R Calne et al. Curr Opin Organ Transplant 16 (4), 353-8. PMID 21666472. - Review
    Follow-up of the 'prope tolerance' protocol has confirmed a low incidence of rejection, infection and post transplant lymphoproliferative disorder (PTLD). Especially, enc …
  • Future Trends in Organ Transplant Recipients--Important Issues for Dermatologists
    D Zecher et al. Curr Probl Dermatol 43, 71-80. PMID 22377921. - Review
    It is on the tip of everyone's tongue in the transplant community that recent improvements in short-term survival of solid organ allografts have not translated into the e …
  • Induction Therapy: Why, When, and Which Agent?
    L Krischock et al. Pediatr Transplant 14 (3), 298-313. PMID 20345609. - Review
    The long-term outcome of paediatric transplantation has improved over the last decade with an increase in the armamentarium of immunosuppressive agents. However, the batt …
See all similar articles

Cited by 14 PubMed Central articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback