Properties of mannitol injection (25%) after repeated autoclavings

Am J Hosp Pharm. 1975 Aug;32(8):826-7.


The physical and chemical properties of mannitol injection 25% were examined after repeated autoclavings. The product was found to be stable after five autoclavings of 250 F for 15 minutes each. No extracts from the rubber closures were found. It is advised that the product may be repeatedly heated or autoclaved if crystals appear as a result of storage.

MeSH terms

  • Drug Packaging
  • Drug Stability
  • Hydrogen-Ion Concentration
  • Mannitol* / analysis
  • Spectrophotometry, Ultraviolet
  • Sterilization


  • Mannitol