Degradation of type I and II collagen by human activated C1-s

FEBS Lett. 1990 Jul 30;268(1):206-8. doi: 10.1016/0014-5793(90)81009-d.


The activated first component of human complement, C1-s, was shown to cleave type I and II collagen and gelatin. The proteolytic activity was heat labile and was inhibited by a monoclonal antibody (M241) which recognized light chain of active human C1-s or by a serine protease inhibitor, DFP, but not by a chelating agent.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Calcium
  • Collagen / metabolism*
  • Complement C1s / metabolism*
  • Enzyme Activation
  • Extracellular Matrix / metabolism
  • Humans
  • Molecular Sequence Data
  • Protease Inhibitors / pharmacology
  • Serine Endopeptidases / genetics
  • Serine Endopeptidases / metabolism


  • Protease Inhibitors
  • Collagen
  • Serine Endopeptidases
  • Complement C1s
  • Calcium