Abstract
DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging 'hallmark' of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Aging*
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Animals
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Energy Metabolism*
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Epigenesis, Genetic
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Gene Expression Regulation, Neoplastic
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Histone Deacetylases / metabolism
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Histones / metabolism
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Humans
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Neoplasms / genetics
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Neoplasms / metabolism*
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Protein Processing, Post-Translational
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Spliceosomes / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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CCAR2 protein, human
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Histones
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Histone Deacetylases
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histone deacetylase 3