The DREAM complex: master coordinator of cell cycle-dependent gene expression

Nat Rev Cancer. 2013 Aug;13(8):585-95. doi: 10.1038/nrc3556. Epub 2013 Jul 11.


The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Cycle / genetics*
  • Cell Cycle Proteins / physiology*
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics*
  • Gene Expression Regulation / physiology*
  • Humans
  • Retinoblastoma Protein / physiology*
  • Transcription Factors / physiology*


  • Cell Cycle Proteins
  • Retinoblastoma Protein
  • Transcription Factors