Plaque vulnerability of coronary artery lesions is related to left ventricular dilatation as determined by optical coherence tomography and cardiac magnetic resonance imaging in patients with type 2 diabetes

Cardiovasc Diabetol. 2013 Jul 11;12:102. doi: 10.1186/1475-2840-12-102.


Background: Patients with type 2 diabetes are at increased risk for both, left ventricular (LV)-dilatation and myocardial infarction (MI) following the rupture of a vulnerable plaque. This study investigated the to date incompletely understood relationship between plaque vulnerability and LV-dilatation using optical coherence tomography (OCT) and cardiac magnetic resonance imaging (CMR) in patients with type 2 diabetes and stable coronary artery disease.

Methods: CMR was performed in 58 patients with type 2 diabetes, in which 81 coronary lesions were investigated using OCT.

Results: A decreased minimal fibrous cap thickness (FCT) of coronary lesions was associated with an increase of several CMR-derived parameters including LV-end diastolic volume (LVEDV, r = 0.521, p < 0.001), LV-end diastolic diameter (r = 0.502, p < 0.001) and LV-end systolic volume (r = 0.467, p = 0.001). Similar results were obtained for mean FCT.

Conclusion: These data suggest that vulnerability of coronary lesions is associated with LV-dilatation in high risk patients with type 2 diabetes. CMR may be a useful adjunct to the risk-stratification in this population. Future studies are warranted to investigate potential mechanisms linking plaque vulnerability and LV-dilatation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Area Under Curve
  • Coronary Artery Disease / diagnosis*
  • Coronary Artery Disease / etiology
  • Coronary Artery Disease / pathology
  • Coronary Vessels / pathology*
  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Fibrosis
  • Heart Ventricles / pathology*
  • Heart Ventricles / physiopathology
  • Humans
  • Hypertrophy, Left Ventricular / diagnosis*
  • Hypertrophy, Left Ventricular / etiology
  • Hypertrophy, Left Ventricular / pathology
  • Hypertrophy, Left Ventricular / physiopathology
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Plaque, Atherosclerotic*
  • Predictive Value of Tests
  • ROC Curve
  • Risk Factors
  • Rupture, Spontaneous
  • Stroke Volume
  • Tomography, Optical Coherence*
  • Ventricular Function, Left