Lemierre syndrome associated with 12th cranial nerve palsy--a case report and review

Int J Pediatr Otorhinolaryngol. 2013 Sep;77(9):1585-8. doi: 10.1016/j.ijporl.2013.05.030. Epub 2013 Jul 8.


Since the widespread availability and use of antibiotics the prevalence of Lemierre syndrome (L.S.) has decreased. It is a well-described entity, consisting of postanginal septicaemia with thrombophlebitis of the internal jugular vein with metastatic infection, most commonly in the lungs. The most common causative agent is a gram-negative, non-spore-forming obligate anaerobic bacterium, Fusobacterium necrophorum (F.n.). We describe the unusual clinical features of a 12-year-old boy with Lemierre syndrome with isolated hypoglossal nerve palsy - the latter symptom is an extremely rare manifestation of this disease.

Keywords: Fusobacterium necrophorum; Lemierre syndrome; Postanginal septicaemia; Septic emboli; Thrombophlebitis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Critical Illness / therapy
  • Follow-Up Studies
  • Fusobacterium Infections / diagnosis*
  • Fusobacterium Infections / drug therapy
  • Fusobacterium necrophorum / drug effects
  • Fusobacterium necrophorum / isolation & purification
  • Humans
  • Hypoglossal Nerve Diseases / diagnostic imaging
  • Hypoglossal Nerve Diseases / etiology*
  • Hypoglossal Nerve Diseases / therapy
  • Intensive Care Units
  • Lemierre Syndrome / diagnosis*
  • Lemierre Syndrome / drug therapy
  • Male
  • Rare Diseases
  • Risk Assessment
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome


  • Anti-Bacterial Agents