IgE-mediated food allergy in children

Lancet. 2013 Nov 16;382(9905):1656-64. doi: 10.1016/S0140-6736(13)60309-8. Epub 2013 Jul 9.

Abstract

Food allergy is a serious health issue affecting roughly 4% of children, with a substantial effect on quality of life. Prognosis is good for the most frequent allergens with almost all children outgrowing their allergy. However, the long-term implications for disease burden are substantial for children with persistent allergies (eg, peanuts, tree nuts, fish, and shellfish) and for those with high concentrations of milk, egg, and wheat IgE. Antigen avoidance has been the time-honoured approach both for prevention and treatment. However, findings from studies done in the past 5 years show that early contact with food can induce tolerance and desensitisation to foods. We review the epidemiology, natural history, and management of food allergy, and discuss the areas of controversy and future directions in research and clinical practice.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Animals
  • Breast Feeding
  • Child
  • Child, Preschool
  • Desensitization, Immunologic / methods*
  • Diet
  • Egg Hypersensitivity / epidemiology
  • Egg Hypersensitivity / immunology
  • Egg Hypersensitivity / therapy
  • Epinephrine / therapeutic use
  • Food Hypersensitivity* / epidemiology
  • Food Hypersensitivity* / immunology
  • Food Hypersensitivity* / therapy
  • Histamine Antagonists / therapeutic use
  • Humans
  • Immunoglobulin E / immunology*
  • Infant
  • Milk Hypersensitivity / epidemiology
  • Milk Hypersensitivity / immunology
  • Milk Hypersensitivity / therapy
  • Nuts / adverse effects
  • Peanut Hypersensitivity / epidemiology
  • Peanut Hypersensitivity / immunology
  • Peanut Hypersensitivity / therapy
  • Seafood / adverse effects
  • Skin Tests
  • Wheat Hypersensitivity / epidemiology
  • Wheat Hypersensitivity / immunology
  • Wheat Hypersensitivity / therapy

Substances

  • Histamine Antagonists
  • Immunoglobulin E
  • Epinephrine