Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection

Brain Behav Immun. 2013 Nov;34:31-8. doi: 10.1016/j.bbi.2013.06.009. Epub 2013 Jul 8.

Abstract

Low socioeconomic status (SES) during childhood and adolescence has been found to predict greater susceptibility to common cold viruses in adults. Here, we test whether low childhood SES is associated with shorter leukocyte telomere length in adulthood, and whether telomere length mediates the association between childhood SES and susceptibility to acute upper respiratory disease in adulthood. At baseline, 196 healthy volunteers reported whether they currently owned their home and, for each year of their childhood, whether their parents owned the family home. Volunteers also had blood drawn for assessment of specific antibody to the challenge virus, and for CD8+ CD28- T-lymphocyte telomere length (in a subset, n=135). They were subsequently quarantined in a hotel, exposed to a virus (rhinovirus [RV] 39) that causes a common cold and followed for infection and illness (clinical cold) over five post-exposure days. Lower childhood SES as measured by fewer years of parental home ownership was associated with shorter adult CD8+ CD28- telomere length and with an increased probability of developing infection and clinical illness when exposed to a common cold virus in adulthood. These associations were independent of adult SES, age, sex, race, body mass, neuroticism, and childhood family characteristics. Associations with infections and colds were also independent of pre-challenge viral-specific antibody and season. Further analyses do not support mediating roles for smoking, alcohol consumption or physical activity but suggest that CD8+ CD28- cell telomere length may act as a partial mediator of the associations between childhood SES and infection and childhood SES and colds.

Keywords: CD8(+)CD28(−); Childhood socioeconomic status; Common cold; Host resistance; Infection; Rhinovirus; Socioeconomic status; Telomere length; Upper respiratory infection; Viral-challenge.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • CD28 Antigens / immunology
  • CD8 Antigens / immunology
  • Common Cold / genetics*
  • Disease Susceptibility
  • Female
  • Humans
  • Male
  • Middle Aged
  • Respiratory Tract Infections / genetics*
  • Rhinovirus / pathogenicity
  • Socioeconomic Factors
  • T-Lymphocytes / immunology
  • T-Lymphocytes / ultrastructure
  • Telomere Homeostasis
  • Telomere*
  • Young Adult

Substances

  • CD28 Antigens
  • CD8 Antigens