Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes

Chem Commun (Camb). 2013 Aug 25;49(66):7286-8. doi: 10.1039/c3cc43334j.

Abstract

Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Cell Line, Tumor
  • Drug Delivery Systems
  • Flow Cytometry
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Micelles*
  • Models, Biological
  • Morpholinos / chemistry*
  • Paclitaxel / pharmacology
  • Polymers / chemistry*

Substances

  • Amines
  • Micelles
  • Morpholinos
  • Polymers
  • Paclitaxel