Abstract
Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry
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Cell Line, Tumor
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Drug Delivery Systems
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Flow Cytometry
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HeLa Cells
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Humans
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Hydrogen-Ion Concentration
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Micelles*
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Models, Biological
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Morpholinos / chemistry*
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Paclitaxel / pharmacology
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Polymers / chemistry*
Substances
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Amines
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Micelles
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Morpholinos
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Polymers
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Paclitaxel