Acute hepatitis associated with clopidogrel: a case report and review of the literature

Am J Ther. 2015 Jan-Feb;22(1):e8-e13. doi: 10.1097/MJT.0b013e318293b0d6.


Drug-induced hepatotoxicity is a common cause of acute hepatitis, and the recognition of the responsible drug may be difficult. We describe a case of clopidogrel-related acute hepatitis. The diagnosis is strongly suggested by an accurate medical history and liver biopsy. Reports about cases of hepatotoxicity due to clopidogrel are increasing in the last few years, after the increased use of this drug. In conclusion, we believe that physicians should carefully consider the risk of drug-induced hepatic injury when clopidogrel is prescribed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Biopsy
  • Chemical and Drug Induced Liver Injury / diagnosis
  • Chemical and Drug Induced Liver Injury / etiology*
  • Clopidogrel
  • Female
  • Humans
  • Middle Aged
  • Platelet Aggregation Inhibitors / adverse effects*
  • Ticlopidine / adverse effects
  • Ticlopidine / analogs & derivatives*


  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine