Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention

Biochemistry (Mosc). 2013 May;78(5):542-8. doi: 10.1134/S0006297913050131.

Abstract

Acute urine retention is a frequent complication in patients with benign hyperplasia of the prostate gland. According to studies made on experimental animals and people, it is accompanied by the deterioration of the bladder blood supply. This study attempts to explore the relationship of intramural blood flow, production of reactive oxygen species, and functional state of the bladder detrusor in modeling of acute urine retention in rats, as well as the impact of mitochondria-targeted antioxidants (which are supposed to alleviate the effects of oxidative stress induced by experimental ischemia) on these parameters. The study showed beneficial effects of mitochondria-targeted antioxidant SkQR1 in preventing damage of the bladder caused by acute urinary retention, which suggests the therapeutic use of this type of compounds for the treatment of ischemic abnormalities of the urinary bladder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Outbred Strains
  • Antioxidants / metabolism
  • Female
  • Humans
  • Mitochondria / metabolism*
  • Oxidative Stress*
  • Reactive Oxygen Species / metabolism
  • Renal Circulation
  • Urinary Bladder / blood supply
  • Urinary Bladder / metabolism
  • Urinary Bladder / physiopathology
  • Urinary Retention / metabolism*
  • Urinary Retention / physiopathology

Substances

  • Antioxidants
  • Reactive Oxygen Species