Age dependent course of EAE in Aire-/- mice

J Neuroimmunol. 2013 Sep 15;262(1-2):27-34. doi: 10.1016/j.jneuroim.2013.06.001. Epub 2013 Jul 9.

Abstract

This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.

Keywords: Autoimmune regulator (Aire); Autoimmunity; Experimental autoimmune encephalomyelitis (EAE); Regulatory T cells (Treg); Susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / genetics*
  • Animals
  • Brain / immunology
  • Brain / physiopathology
  • Cell Count
  • Disease Models, Animal
  • Disease Susceptibility / physiopathology
  • Encephalomyelitis, Autoimmune, Experimental / genetics*
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Spleen / immunology
  • Spleen / physiopathology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / pathology
  • Time Factors
  • Transcription Factors / deficiency*
  • Transcription Factors / genetics*

Substances

  • APECED protein
  • Transcription Factors