The clinical value of 18F-FDG PET/CT in the evaluation of bone metastases undetermined origin

Clin Imaging. 2013 Sep-Oct;37(5):922-4. doi: 10.1016/j.clinimag.2013.03.004. Epub 2013 Jul 12.

Abstract

Purpose: To evaluate the clinical value of (18)F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) in detection of primary lesions of bone metastases.

Methods: The PET/CT scans of 77 patients with bone metastases undetermined origin were retrospectively reviewed. The results of clinical information were collected.

Results: Forty-four suspected primary tumors were found on the PET/CT images in 77 patients of bone metastases, including 40 patients with the primary tumor confirmed, and 4 patients false-positive. In 37 patients, no primary lesions were detected, including one patient false-negative (signet-ring cell carcinoma). The sensitivity, specificity, and accuracy was 97.6%, 88.9%,and 93.5% respectively. The primary lesions of 51.9% patients could be diagnosed by PET/CT.

Conclusion: PET/CT is helpful in detecting the primary lesions of bone metastases.

Keywords: (18)F-FDG; Bone metastases; PET/CT; Primary lesions.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / secondary*
  • Carcinoma, Signet Ring Cell / diagnosis
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Middle Aged
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals
  • Retrospective Studies
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*
  • Ultrasonography

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18